![]() SPINAL IMPLANT
专利摘要:
spinal fusion compartment that has adjustable dimensions in the postoperative period. the present invention relates to a spinal implant that includes first spinal fixation member for fixation to a first spinal part, second spinal fixation member for fixation to a second spinal part, and a post-implantation variable size device disposed between the first and second spinal fixation members, which can be operated after the end of the surgery, in which said spinal implant was installed in a patient, to cause the relative movement between the first and second spinal fixation members. 公开号:BR112012012498B1 申请号:R112012012498-6 申请日:2010-11-05 公开日:2020-09-24 发明作者:Uri Arnin 申请人:Spine21 Ltd.; IPC主号:
专利说明:
[0001] [0001] The present invention relates, in general, to spinal implants and prostheses and, in particular, to a spinal fusion compartment that has adjustable dimensions in the postoperative period. Background of the Invention [0002] [0002] Spinal implants with the ability to adjust height are known. A device is shown and described in the PCT patent application PCT / IL2008 / 001423 (WO 2009/060427) for the present Applicant. One of the devices shown therein uses a screwed and tilted interface between the first and second support plates, as is now described with reference to figure 1. [0003] [0003] The prior art device is a spinal implant 50 that includes a post-implantation variable size device 52, used to change the location of adjacent vertebrae 51 and 53. The spinal implant 50 includes a first support plate (upper) 54 which has a screwed slot, in which a screwed thread 55 is received in a screwed manner. The spinal implant 50 includes a second support plate (bottom) 56 that includes a recess, on which an electric motor (or actuator) 57 is mounted. The electric motor 57 (which can be controlled remotely) turns the thread 55, which causes the first support plate 54 to slide in relation to the second support plate 56. The inclined adjustment between the first and second support plates ( the spinal fixation members) 54 and 56 causes a change in the adjacent location between the two vertebrae, both in the vertical and in the sagittal plane. Summary of the Invention [0004] [0004] The present invention seeks to provide an improved spinal implant (or prosthesis, the terms being used interchangeably) that has adjustable dimensions in the postoperative period, to be positioned between two adjacent vertebrae, with the ability to adjust both the height between the vertebrae as well as the sagittal position in relation to each other. In contrast to the prior art above, in the present invention, the angled interface is not screwed; instead, the vertebral fixation members slide over each other by means of inclined alignment rails. [0005] [0005] In one modality, at least one of the dimensions of the spinal implant can be modified in the post-implantation by means of remote control. The adjustable mechanism (also called a variable dimension mechanism) can have an inclined alignment rail. The adjustment of the height and the sagittal location of the compartment parts, in relation to each other, can be powered electrically, such as by means of an electric motor (powered by a battery or remote induction) and controlled via remote control. The prosthesis is configured to bridge the two vertebrae, with maximum preference, but not limited to the adjacent vertebrae. The prosthesis includes a plurality of fixation members (final features) configured to be fixed to a plurality of bone fixation points, for example, but not limited to, vertebral end plates. [0006] [0006] Thus, according to a non-limiting embodiment of the present invention, there is presented a spinal implant that includes the first spinal fixation member for fixation to a first spinal part, the second spinal fixation member for fixation to a second spinal part, and a post-implantation variable-size device arranged between the first and second spinal fixation members, which can be operated after the end of the surgery, in which the spinal implant was installed in a patient, to cause the relative movement between the first and second spinal fixation members. [0007] [0007] According to an embodiment of the present invention, the first and second spinal fixing members include an inclined alignment rail. [0008] [0008] According to one embodiment of the present invention, the post-implantation variable-size device alters a distance between the first and second spinal fixation members [0009] [0009] According to one embodiment of the present invention, the post-implantation variable dimension device alters a location of the first and second spinal fixation members both in the vertical and in the sagittal plane. [0010] [00010] According to an embodiment of the present invention, the first spinal fixation member includes a slot (channel) and a traction element disposed in that slot attracts or impels that first fixation member with respect to the second fixation member. [0011] [00011] According to an embodiment of the present invention, the drive element is actuated by a threaded shaft that is rotated by a gear train, in which the rotation of the gear train changes the distance between the first and second support plates . [0012] [00012] According to an embodiment of the present invention, the first and second spinal fixing members include the first and second alignment tracks inclined with respect to each other. [0013] [00013] According to an embodiment of the present invention, the post-implantation variable dimension device is operated in a hydraulic or pneumatic manner. [0014] [00014] According to an embodiment of the present invention, the post-implantation variable dimension device is operated electrically. [0015] [00015] According to an embodiment of the present invention, the post-implantation variable dimension device includes an internal, implanted part. The interior may include at least one of a piston, a pump, a microprocessor, an RF emitter / transmitter, an LVDT (linear variable differential transducer), a voltage sensor, an electrical coil, a battery and a capacitor. [0016] [00016] According to an embodiment of the present invention, the post-implantation variable dimension device includes an external control piston. The external control part may include at least one of a control panel, a processor, an RF transmitter / emitter, a magnetic power supply, an electrical coil and a cellular communication device. Communication between the external control part and the implanted part can be controlled by a code or a password to protect against unwanted operation of the internal device. Brief Description of Drawings [0017] [00017] The present invention will be understood and observed more completely from the detailed description below, considered together with the drawings in which: figure 1 is a simplified pictorial illustration of a spinal implant that includes a device of variable size after implantation of the prior art; figure 2 is a simplified partially cross-sectional illustration of a spinal implant that includes a post-implantation variable size device, constructed and operational in accordance with an embodiment of the invention; figure 3 is a simplified pictorial illustration of inclined alignment tracks of the device of figure 2, according to an embodiment of the invention; figure 4 is a simplified illustration of a spinal implant that includes a post-implantation variable-size device, constructed and operational according to another embodiment of the invention; Figure 5 is a simplified illustration of a spinal implant that includes a post-implantation variable size device constructed and operational in accordance with yet another embodiment of the present invention; and. figure 6 is a simplified illustration of a piston actuated by fluid in the configuration of the mode of figure 4. Detailed Description of the Modalities [0018] [00018] Reference is now made to figure 2, which illustrates a spinal implant 100, constructed and operational according to a non-limiting modality of the invention. [0019] [00019] Spinal implant 100 is shown implanted between two adjacent vertebrae 101 and 102. Spinal implant 100 includes a first spinal fixation member (eg, upper) 104 arranged to slide through a second spinal fixation member (eg, bottom) 103. More specifically, the first and second fixing members 104 and 103 include at least one inclined alignment rail 110 that slides through at least one inclined channel 109 (the rail or rails are formed on one of the fixing members and the channel or channels are formed on the other fixation member). (The tracks and channels are not visible in the section in figure 2, but an example of them is shown in figure 3). The first fixation member 104 slides through the second fixation member 103 when it is attracted or driven by a traction element 107. The first and second fixation members 104 and 103 form a spinal fusion compartment that has the dimensions adjustable post-operatively. . [0020] [00020] The surfaces of the fixation members in contact with the bone can be coated to promote bone integration. [0021] [00021] According to a non-limiting embodiment of the invention, the traction element 107 includes a distal tongue 111 which is received in a recess 112 formed in the first fixing member 104. A proximal rod 113 of the traction element 107 is screwed in internal way to match a threaded rod 105 (also called thread 105). The first clamping member 104 is sufficiently hollow to allow the threaded rod 105 to enter and advance to the first clamping member 104. The threaded rod 105 can be rotated by a gear system 108, actuated by a powered gear train by an actuation motor, not shown here, but shown in figure 4. A seal 106 can be arranged between components located in a closed compartment and elements exposed to the human body. [0022] [00022] According to a non-limiting embodiment of the present invention, the traction element 107 and the threaded rod 105 are completely or partially arranged in the fixing member 103. A bearing element, like any type of bearing, lubrication, treatment of surface and the like, can be used to reduce friction between the pulling element 107 and / or the threaded rod 105 and the fastening members 103 and / or 104. [0023] [00023] According to an embodiment of the present invention, the gear system 108 can be the toothed wheel, the worm gear, the belt, the chain or other known mechanisms for transmitting the movement. [0024] [00024] Reference is now made to figure 3, which shows the inclined alignment rails 110, according to a non-limiting embodiment of the invention. Alignment track 110 can be a pre-designed angle to create different relationships between sagittal and vertical translations. At least one alignment rail 110 may be located symmetrically around the center of the device or non-symmetrically around the center (e.g., off center). The sliding surface of the channels 109 can include a bearing element 117, like any type of bearing, lubrication, surface treatment and the like, to reduce friction. The illustrated embodiment shows at least one alignment rail 110 with a generally rectangular shape; however, different shapes can be used, as well as to carry out the invention, but that does not include the fit, the round shape, the T shape or any other shapes. [0025] [00025] Reference is now made to Figure 4, which illustrates a cross section of a spinal implant that includes a post-implantation variable-size device constructed and operational in accordance with an embodiment of the present invention. [0026] [00026] A drive element 305 is attracted by a threaded rod 304. Threaded rod 304 is connected to a gear train 309, powered by a 303 actuation motor. A battery 306 and a printed circuit 307 are used to control the motor 303. A seal 308 is used to separate between the encapsulated elements and the human body, not shown. [0027] [00027] According to an embodiment of the present invention, the printed circuit 307 can include at least one of a microcontroller, a radio system, a remote switch, a capacitor and an induction coil. The electrical components can be controlled by an external unit via remote control (radio, light, voice, etc.). Instead of being actuated electrically, the 303 actuation motor can be hydraulic or pneumatic. [0028] [00028] Reference is now made to figure 5, which illustrates a cross section of a spinal implant that includes a post-implantation variable size device constructed and operational in accordance with another embodiment of the present invention. In this embodiment, the drive element includes a piston 320 with a stem 321. A tongue 322 at a distal end of the stem 321 is received in a recess 323 formed in the first fixing member 104. The piston 320 can be operated electrically, pneumatic or hydraulic (ie fluidly). [0029] [00029] Figure 6 illustrates an example of a hydraulic or pneumatic piston 320 in the configuration of the mode of figure 4. The traction element 305 is at the distal end of the stem 321. The piston 320 is operated by a hydraulic or pneumatic pump (ie ie, fluid) 324, connected to it by a tube 325. [0030] [00030] The modalities of figures 2 to 6 can be interchanged and / or integrated with each other in different combinations.
权利要求:
Claims (9) [0001] Spinal implant (100) comprising: first and second spinal fixing members (104, 103) which comprise at least one inclined alignment rail (110) which slides through at least one inclined channel (109); and a traction element (107) arranged to cause the first and second spinal fixing members (104, 103) to slide relative to each other by means of said at least one inclined alignment track (110) and said at least an inclined channel (109); wherein the proximal end (113) of said traction element (107) is threaded internally and coincides with a threaded rod (105), and characterized by the fact that said threaded rod (105) is rotated by a gear system (108) powered by an actuation motor (303), and said actuation motor (303) is controlled by a printed circuit (307) , which comprises at least one of a microcontroller, a radio system, a remote switch, a capacitor and an induction coil. [0002] Spinal implant (100) according to claim 1, characterized in that said traction element (107) comprises a distal tongue (111) which is received in a recess (112) formed in said first fixation member ( 104). [0003] Spinal implant (100), according to claim 1, characterized by the fact that said at least one alignment rail (110) has a pre-designed angle to create different relationships between the sagittal and vertical translations of said first and second spinal fixation members (104, 103) when sliding in relation to each other. [0004] Spinal implant (100), according to claim 1, characterized by the fact that said at least one alignment track (110) is located symmetrically around a center of said implant (100). [0005] Spinal implant (100), according to claim 1, characterized by the fact that said at least one alignment track (110) is not situated symmetrically around a center of said implant (100). [0006] Spinal implant (100), according to claim 1, characterized in that the surfaces of said first and second spinal fixation members (104, 103) in contact with the bone are coated to promote bone integration. [0007] Spinal implant (100) according to claim 1, characterized in that a sliding surface of said channels (109) comprises a bearing element (117). [0008] Spinal implant (100), according to claim 1, characterized by the fact that said traction element is moved by a piston (320) with a rod (321). [0009] Spinal implant (100) according to claim 8, characterized by the fact that said piston (320) is a piston actuated by fluid connected to a fluid pump (324) by a tube (325).
类似技术:
公开号 | 公开日 | 专利标题 BR112012012498B1|2020-09-24|SPINAL IMPLANT BR112012012541B1|2020-03-24|Spinal implant ES2450365T3|2014-03-24|Spine implant that has an adjustable postoperative dimension ES2861223T3|2021-10-06|Spinal distraction system US9049987B2|2015-06-09|Hand held surgical device for manipulating an internal magnet assembly within a patient ES2223191T3|2005-02-16|DISTRACTION DEVICE. US8888731B2|2014-11-18|Systems, devices, and methods including infection-fighting and monitoring shunts ES2701241T3|2019-02-21|Implantable Occlusive System US20120053633A1|2012-03-01|Actuator for correcting scoliosis BRPI0817871B8|2021-06-22|device for controlling the flow in an organ of the body BR112017007188A2|2017-12-19|cup impact element BR112018008121A2|2018-11-06|medical device for use within a tubular body having a lumen, method for recording neural information or stimulation of a patient's neurons, and system for controlling equipment coupled with an animal or human ES2563853T3|2016-03-16|Improved implantable device for the treatment of hydrocephalic syndrome and the corresponding method ES2879405T3|2021-11-22|Bone transport systems BR0013285A|2002-07-02|Intervertebral disc and cavity implant prostheses, methods of herniated disc repair, support of the intervertebral disc nucleus pulpus in the dorsal spine, closure of anomaly in the intervertebral disc annulus and a separation structure of two anatomical regions prosthesis fabrication, intervertebral disc membrane insertion and dynamically stable implant positioning, intervertebral disc and prosthesis assembly, living tissue hermetic soft-tissue anomaly closure system, pre- dissection, intervertebral disc dissector and dissection device ES2459866B1|2015-02-17|WALKER WITH ASSISTANCE MECHANISM IN SURVEY OPERATIONS AND SITTING OF A USER. CN108778197A|2018-11-09|Sphincter type enteron aisle valve ES2567282T3|2016-04-21|Interspinous vertebral separator ES2687707T3|2018-10-26|Electrically activated valve, in particular programmable hydrocephalus valve Roldán et al.2018|Device for the Treatment of Hydrocephalus: Experimental Protocol in an Animal Model US11266829B2|2022-03-08|Universal power supply for a functional cranial implant ES2742159T3|2020-02-13|Prevention of compression of a vertebral implant RU2017126104A|2019-01-31|GUIDING DEVICE FOR PLANNING AND DRILLING HOLES FOR DENTAL IMPLANTS Arenberg et al.1979|Endolymphatic sac valve implant surgery: II: The unidirectional inner ear valve implant Sipkin et al.2013|Maxillary sinusitis: a contemporary view on the diagnostics, therapy and rehabilitation
同族专利:
公开号 | 公开日 US8870959B2|2014-10-28| US20120277875A1|2012-11-01| BR112012012498A2|2017-10-10| CN102740788A|2012-10-17| CN102740788B|2016-04-20| EP2503963A2|2012-10-03| JP2013512005A|2013-04-11| WO2011066077A2|2011-06-03| WO2011066077A3|2011-09-29|
引用文献:
公开号 | 申请日 | 公开日 | 申请人 | 专利标题 US8003A|1851-03-25|Improvement in scythe-tastenings | US7027A|1850-01-15|Circulak | JP2001511392A|1997-08-04|2001-08-14|ゴードン,メイヤ,ロバーツアンドトーマスナンバー1リミティドライアビリティーカンパニー|Multiaxial intervertebral prosthesis| US5865848A|1997-09-12|1999-02-02|Artifex, Ltd.|Dynamic intervertebral spacer and method of use| DE20308171U1|2003-05-21|2003-07-31|Aesculap Ag & Co Kg|Vertebral body replacement implant| US7850733B2|2004-02-10|2010-12-14|Atlas Spine, Inc.|PLIF opposing wedge ramp| US7211112B2|2004-02-10|2007-05-01|Atlas Spine|Spinal fusion device| US7799081B2|2004-09-14|2010-09-21|Aeolin, Llc|System and method for spinal fusion| US7942903B2|2005-04-12|2011-05-17|Moskowitz Ahmnon D|Bi-directional fixating transvertebral body screws and posterior cervical and lumbar interarticulating joint calibrated stapling devices for spinal fusion| US8241331B2|2007-11-08|2012-08-14|Spine21 Ltd.|Spinal implant having a post-operative adjustable dimension|US7041309B2|2002-06-13|2006-05-09|Neuropro Technologies, Inc.|Spinal fusion using an HMG-CoA reductase inhibitor| US8597360B2|2004-11-03|2013-12-03|Neuropro Technologies, Inc.|Bone fusion device| US9526525B2|2006-08-22|2016-12-27|Neuropro Technologies, Inc.|Percutaneous system for dynamic spinal stabilization| US7862502B2|2006-10-20|2011-01-04|Ellipse Technologies, Inc.|Method and apparatus for adjusting a gastrointestinal restriction device| US20090112262A1|2007-10-30|2009-04-30|Scott Pool|Skeletal manipulation system| US11202707B2|2008-03-25|2021-12-21|Nuvasive Specialized Orthopedics, Inc.|Adjustable implant system| US8382756B2|2008-11-10|2013-02-26|Ellipse Technologies, Inc.|External adjustment device for distraction device| US8197490B2|2009-02-23|2012-06-12|Ellipse Technologies, Inc.|Non-invasive adjustable distraction system| US9622792B2|2009-04-29|2017-04-18|Nuvasive Specialized Orthopedics, Inc.|Interspinous process device and method| KR101740218B1|2009-09-04|2017-05-25|누베이시브 스페셜라이즈드 오소페딕스, 인크.|Bone growth device and method| US10245159B1|2009-09-18|2019-04-02|Spinal Surgical Strategies, Llc|Bone graft delivery system and method for using same| US10973656B2|2009-09-18|2021-04-13|Spinal Surgical Strategies, Inc.|Bone graft delivery system and method for using same| US8906028B2|2009-09-18|2014-12-09|Spinal Surgical Strategies, Llc|Bone graft delivery device and method of using the same| US9248043B2|2010-06-30|2016-02-02|Ellipse Technologies, Inc.|External adjustment device for distraction device| WO2012007918A2|2010-07-15|2012-01-19|Nonlinear Technologies Ltd.|Surgical systems and methods for implanting deflectable implants| US8734488B2|2010-08-09|2014-05-27|Ellipse Technologies, Inc.|Maintenance feature in magnetic implant| US8715282B2|2011-02-14|2014-05-06|Ellipse Technologies, Inc.|System and method for altering rotational alignment of bone sections| WO2013023098A1|2011-08-09|2013-02-14|Neuropro Spinal Jaxx Inc.|Bone fusion device, apparatus and method| US10292830B2|2011-08-09|2019-05-21|Neuropro Technologies, Inc.|Bone fusion device, system and method| US10420654B2|2011-08-09|2019-09-24|Neuropro Technologies, Inc.|Bone fusion device, system and method| US10743794B2|2011-10-04|2020-08-18|Nuvasive Specialized Orthopedics, Inc.|Devices and methods for non-invasive implant length sensing| US9198765B1|2011-10-31|2015-12-01|Nuvasive, Inc.|Expandable spinal fusion implants and related methods| WO2013066946A1|2011-11-01|2013-05-10|Ellipse Technologies, Inc.|Adjustable magnetic devices and methods of using same| US10159583B2|2012-04-13|2018-12-25|Neuropro Technologies, Inc.|Bone fusion device| US9532883B2|2012-04-13|2017-01-03|Neuropro Technologies, Inc.|Bone fusion device| EP2854715A1|2012-05-29|2015-04-08|NLT Spine Ltd.|Laterally deflectable implant| US9078711B2|2012-06-06|2015-07-14|Ellipse Technologies, Inc.|Devices and methods for detection of slippage of magnetic coupling in implantable medical devices| US9044281B2|2012-10-18|2015-06-02|Ellipse Technologies, Inc.|Intramedullary implants for replacing lost bone| US9445918B1|2012-10-22|2016-09-20|Nuvasive, Inc.|Expandable spinal fusion implants and related instruments and methods| CN104902854B|2012-10-29|2017-10-03|诺威适骨科专科公司|The adjustable apparatus scorching for treating knee endoprosthesis| US9585765B2|2013-02-14|2017-03-07|Globus Medical, Inc|Devices and methods for correcting vertebral misalignment| US9782265B2|2013-02-15|2017-10-10|Globus Medical, Inc|Articulating and expandable vertebral implant| US9179938B2|2013-03-08|2015-11-10|Ellipse Technologies, Inc.|Distraction devices and method of assembling the same| AU2014236698B2|2013-03-15|2018-09-13|Neuropro Technologies, Inc.|Bodiless bone fusion device, apparatus and method| US9788971B1|2013-05-22|2017-10-17|Nuvasive, Inc.|Expandable fusion implant and related methods| US10149770B2|2013-07-09|2018-12-11|Seaspine, Inc.|Orthopedic implant with adjustable angle between tissue contact surfaces| US10226242B2|2013-07-31|2019-03-12|Nuvasive Specialized Orthopedics, Inc.|Noninvasively adjustable suture anchors| US9801734B1|2013-08-09|2017-10-31|Nuvasive, Inc.|Lordotic expandable interbody implant| US10751094B2|2013-10-10|2020-08-25|Nuvasive Specialized Orthopedics, Inc.|Adjustable spinal implant| WO2015063721A1|2013-10-31|2015-05-07|Nlt Spine Ltd.|Adjustable implant| WO2015087285A1|2013-12-11|2015-06-18|Nlt Spine Ltd.|Worm-gear actuated orthopedic implants & methods| WO2015168175A1|2014-04-28|2015-11-05|Ellipse Technologies, Inc.|System for informational magnetic feedback in adjustable implants| US9861491B2|2014-04-30|2018-01-09|Depuy Ireland Unlimited Company|Tibial trial system for a knee prosthesis| WO2015198335A1|2014-06-25|2015-12-30|Nlt Spine Ltd.|Expanding implant with hinged arms| BR112017013834A2|2014-12-26|2019-11-19|Nuvasive Specialized Orthopedics Inc|distraction systems and methods| US10238427B2|2015-02-19|2019-03-26|Nuvasive Specialized Orthopedics, Inc.|Systems and methods for vertebral adjustment| CN104739549A|2015-04-16|2015-07-01|黄哲宇|Slanted slot type interbody fusion cage| CN113425401A|2015-10-16|2021-09-24|诺威适骨科专科公司|Adjustable device for treating gonitis| CN108601611B|2015-12-10|2021-11-02|诺威适骨科专科公司|External adjustment device for a tensioning device| EP3407812B1|2016-01-28|2020-07-01|NuVasive Specialized Orthopedics, Inc.|Systems for bone transport| CN105769392B|2016-04-05|2018-08-14|广州爱锘德医疗器械有限公司|Threaded fusion cage| CN105708536B|2016-04-26|2018-02-23|山东省文登整骨医院|Adjustment height anchor goes out formula Invasive lumbar fusion device| CN105796215B|2016-05-27|2017-12-15|瞿玉兴|Lumbar intervertebral fusion device can be strutted| US10111760B2|2017-01-18|2018-10-30|Neuropro Technologies, Inc.|Bone fusion system, device and method including a measuring mechanism| US10213321B2|2017-01-18|2019-02-26|Neuropro Technologies, Inc.|Bone fusion system, device and method including delivery apparatus| US10729560B2|2017-01-18|2020-08-04|Neuropro Technologies, Inc.|Bone fusion system, device and method including an insertion instrument| US10973657B2|2017-01-18|2021-04-13|Neuropro Technologies, Inc.|Bone fusion surgical system and method| CN110974492B|2019-10-29|2021-08-03|郑州大学第一附属医院|Under-mirror reset type lumbar spondylolisthesis interbody fusion cage|
法律状态:
2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]| 2019-07-23| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]| 2020-02-11| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]| 2020-06-30| B09A| Decision: intention to grant [chapter 9.1 patent gazette]| 2020-09-24| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/11/2010, OBSERVADAS AS CONDICOES LEGAIS. |
优先权:
[返回顶部]
申请号 | 申请日 | 专利标题 US27295909P| true| 2009-11-24|2009-11-24| US61/272,959|2009-11-24| PCT/US2010/055532|WO2011066077A2|2009-11-24|2010-11-05|Spinal fusion cage having post-operative adjustable dimensions| 相关专利
Sulfonates, polymers, resist compositions and patterning process
Washing machine
Washing machine
Device for fixture finishing and tension adjusting of membrane
Structure for Equipping Band in a Plane Cathode Ray Tube
Process for preparation of 7 alpha-carboxyl 9, 11-epoxy steroids and intermediates useful therein an
国家/地区
|